Age difference is irrelevant if you love each other. My grandfather was 20 years older than my grandmother and they had an amazing life for 37 years with 2 great children.
I think just make sure her character is strong. Some women are already grown up at 22 but many are not.
This, if you're talking about relationship material then as long as she's emotionally mature and can hold a conversation it's fine. Older man/younger woman is fairly natural. If a guy habitually and exclusively dates women much younger, then I would probably find it a bit creepy as younger women are less able to realize when a guy is a dud.